Acute hypoxemic respiratory failure +Â bilateral lung opacities = ARDS
Results from disruption of surfactant, vascular endothelial injuries, and alveolar epithelial injury
Use low-tidal volume ventilation (TV: 4-8 mL/kg of predicted BW and PPlateu < 30 cmH2O) and PEEP
PEEP should be set to maintain SpO2 between 88-95%
High concentration of oxygen can be damaging
Prone positioning should be considered for all patients with severe ARDS in addition to PEEP and low tidal volume ventilation
Permissive hypercapnia is acceptable in ARDS
Evaluate for cardiomyopathy, mitral and aortic valve disease, myocardial ischemia, and arrhythmias
Focus on reduction of preload and afterload (diuretics, vasodilators, or inodialators)